After opening up of the economy in most sectors, 1991 onwards, this industry has been no Nanobiotechnology is a recently coined term describing the junction of the two existing but isolated worlds of engineering and molecular biology. It is a combination of three words: “nano” tiny, “bio” is living things, and “technology” is about tools. It refers to the ability to create and manipulate biological and biochemical materials, devices, and systems at atomic and molecular levels. Thus, it is an integration of physical sciences, molecular engineering, biology, chemistry, and biotechnology, and holds considerable promise of advances in pharmaceuticals and health care. Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Their unique size-dependent properties make these materials superior, crucial in many areas of human activity, and above all a tiny tool to learn about living things. Consequently it applies the tools and processes of nanofabrication to build devices for studying biosystems. In this review we discussed the role of nanobiotechnology in molecular diagnosis, drug discovery, and development of nanomedicine and personalized medicine. The FDA approval is essential for clinical applications of nanotechnology and substantial regulatory problems could be encountered in the approval of nanotechnology-based products therefore we also discussed about the limitations of use of nanobiotechnology in drug discovery.
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